|
KMID : 1098420100180040238
|
|
Korean Journal of Medicinal Crop Science
2010 Volume.18 No. 4 p.238 ~ p.243
|
|
|
Antinociception Effect and Mechanisms of Viola tricolor L. Extract in Mouse
|
|
Park Soo-Hyun
Sim Yun-Beom
Suh Hong-Won
Kim Jin-Kyu
Lee Jin-Koo
Lim Soon-Sung
|
|
|
Abstract
|
|
|
|
In the present study, the antinociceptive profiles of Viola tricolor L. (V. tricolor L.) extract were examined in ICR mice. V. tricolor L. extract administered orally (200㎎/㎏) showed an antinociceptive effect as measured by the tail-flick and hot-plate tests. In addition, V. tricolor L. extract attenuated the writhing numbers in the acetic acid-induced writhing test. Furthermore, the cumulative nociceptive response time for intrathecal (i.t.) injection of substance P (0.7 ㎍) was diminished by V. tricolor L. extract. Intraperitoneal (i.p.) pretreatment with yohimbine (α2-adrenergic receptor antagonist) attenuated antinociceptive effect induced by V. tricolor L. extract in the writhing test. However, naloxone (opioid receptor antagonist) or methysergide (5-HT serotonergic receptor antagonist) did not affect antinociception induced by V. tricolor L. extract in the writhing test. Our results suggest that V. tricolor L. extract shows an antinociceptive property in various pain models. Furthermore, this antinociceptive effect of V. tricolor L. extract may be mediated by α2-adrenergic receptor, but not opioidergic and serotonergic receptors.
|
|
|
KEYWORD
|
|
|
Viola tricolor L., Anti-Nociception, Inflammatory Pain, α2-adrenoceptor
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|